404-86-4 Capsaicin manufacturer Capsaicin good supplier CAS NO.404-86-4

Min.Order: 1 Kilogram
Payment Terms: L/C,T/T,Other

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404-86-4 Capsaicin manufacturer
Capsaicin good supplier
404-86-4 fast delivery

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ProName: 404-86-4 Capsaicin manufacturer Capsai...
CasNo: 404-86-4
Molecular Formula: C15H22O2
Appearance: Light yellow to white crystal powder
Application: Plant extract
DeliveryTime: in stock
PackAge: 1 kg/bag,or according to the requireme...
Port: Shanghai,Qingdao or others
ProductionCapacity: 2000 Metric Ton/Year
Purity: 99%
Storage: Keep undercool, dry and well ventilate...
Transportation: by sea or by air
LimitNum: 1 Kilogram
Related Substances: refer to COA
Residue on Ignition: 3-5 YEARS

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404-86-4 Capsaicin manufacturer Capsaicin good supplier

Extraction method

1. Solvent extraction Solvent extraction method is the use of petroleum ether, ethanol, acetone and other single solvent or mixed solvent, the pepper skin grinding, room temperature stirring, leaching, filtration for several times. For example, with capsaicin as the raw material, 10% sodium hydroxide solution was used to extract, stirred at 60℃ for 5h, then stratified, the lower water was added with diluted hydrochloric acid to adjust the pH to 5, and the crude capsaicin compounds were extracted twice by petroleum ether and acetone, concentrated and crystallized, with the yield of 70.64% and the purity of 93.5% after recrystallization by ethyl ether.

2. Ultrasonic extraction Compared with traditional extraction, ultrasonic extraction has the advantages of high yield, short production cycle, no heating and no destruction of active ingredients. For example, under the conditions of 1:15 solid-liquid ratio,70% ethanol as the extraction solvent, extraction temperature 60℃, ultrasonic frequency 28kHz, power 120W, extraction time 20min, the yield of capsaicin was 2.819mg/g, the extraction rate was 64.2%, the extraction rate for three consecutive times reached 89.4%, nearly 20% higher than the traditional ethanol extraction method.

3. Microwave-assisted extraction: The capsaicin was extracted by microwave pretreatment with acetic acid. Each gram of capsaicin was soaked with 1ml 10% acetic acid as gasifier for 15min and pre-treated with microwave power of 480W after 90s.

4. Supercritical fluid extraction supercritical fluid extraction is a relatively new extraction separation technology, which effectively overcomes the shortcomings of traditional separation methods. It uses high pressure gas above critical temperature as a solvent to separate, extract and refine effective components. For example, supercritical extraction of capsaicin from Xinjiang capsaicin was performed under the conditions of extraction pressure of 12MPa, extraction temperature of 45 ° C, separation temperature of 45 ° C, extraction time of 40min, and the ratio of solid to liquid of anhydrous ethanol as the binder. The extraction rate of capsaicin reached 5.0mg/g, which was higher than the traditional solvent extraction method. Supercritical fluid extraction (SFE) is characterized by high extraction speed, low solvent and impurity content, but its high equipment cost is an important factor restricting its industrial production.

5. Enzymatic method At present, enzymatic extraction has been widely used in the extraction of plant active components, such as the extraction of safflower yellow pigment by enzymatic method, the extraction of flavonoids by enzymatic method. Because capsaicin and other fat-soluble components are present in the uneven fibrous tissue of the skin of capsaicin, enzymatic hydrolysis of the fibrous tissue can dissolve the capsaicin. For example, the capsaicin in dry red capsaicin was extracted with cellulase. The extraction conditions were as follows: the enzymatic hydrolysis temperature was 55℃, the initial pH of the enzymatic hydrolysate was 5.4, the enzymatic hydrolysis time was 4h, and the enzyme amount was 2.5mg/g capsaicin. The yield of natural capsaicin was 7.65mg/g capsaicin, which increased by 33% compared with the traditional ethanol extraction method.

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Purification methods

At present, the most widely used methods for purification of capsaicin include macroporous adsorption resin column chromatography, chitosan resin method and ion exchange method.

1. Macroporous adsorption resin method: Macroporous adsorption resin method is a modern extraction and separation method for natural products, which is characterized by simple operation, low cost and high yield. For example, after extracting the ethanol extract of capsaicin with dilute ethanol, the aqueous ethanol was used as eluent to enrich capsaicin with macroporous adsorption resin column. This method has the advantages of high extraction rate and purity, low cost and easy operation.

2. Chitosan is a kind of basic polysaccharide. The amino group can bind the phenolic transgroup of capsaicin. Based on this property, chitosan resin was used to adsorb and purify the initial extract of capsaicin. After recrystallization, the purity and yield of capsaicin were higher and the cost was lower, which was conducive to industrial production. For example, the capsaicin extracted from weak base solution was defatted, adsorbed with chitosan resin column, eluted with ethanol, and recrystallized. The purity of capsaicin crystal was determined by HPLC. At present, the production technology of capsaicin is generally complicated, and the extraction rate and yield are low. Chitosan resin adsorption and extraction process is simple, low price and high purity, which has certain significance in industrial production.

3. Raw ion exchange method to capsaicin as raw material, its soluble in 1% naoh solution, with 2% sulfuric acid acidification to pH = 3.0, n-hexane extraction, concentration and crystallization, to the purity of 82% ~ 84% of the crude products of capsaicin, then soluble in sodium hydroxide solution, using anion exchange resin purification, ethanol, ethyl acetate of vinegar (volume ratio 45:55) mixed solvent wash, concentration and crystallization can get high purity capsaicin purity is more than 98.5%.